| Date | Opponent | Time (CT) / result | TV, Radio / Attendance |
| April |
| 04/01 - Saturday | @ FC Dallas | L, 2-3 | 19,377 |
| 04/08 - Saturday | @ Los Angeles Galaxy | T, 1-1 | 19,107 |
| 04/15 - Saturday | @ Columbus Crew | T, 1-1 | 20,818 |
| 04/30 - Sunday | @ New England Revolution | W, 2-1 2:00 p.m. | ESPN2, DK - 11,762 |
| May |
| 05/06 - Saturday | @ Kansas City Wizards | T, 1-1 7:30 p.m. | HDNet - 8,138 |
| 05/13 - Saturday | @ New York Red Bulls | T, 1-1 6:30 p.m. | DK, CSN - 8,712
|
| 05/20 - Saturday | @ Houston Dynamo | W, 1-0 3:00 p.m. | ESPN2 |
| 05/27 - Saturday | @ Chivas USA | L, 0-1 10:00 p.m. | DK, CSN - 14,816 |
| June |
| 06/03 - Saturday | @ Real Salt Lake | L, 1-3 8:00 p.m. | DK, CSN - 14,752 |
| 06/11 - Sunday | New England Revolution | T, 3-3 6:00 p.m. | 12,941 |
| 06/17 - Saturday | @ Kansas City Wizards | L, 3-2 7:30 p.m. | 9,014 |
| 06/21 - Wednesday | @ D.C. United | L, 1-0 6:30 p.m. | 12,385 |
| 06/25 - Sunday | New York Red Bulls | W, 2-0 6:00 p.m. | DK, CSN - 20,133 |
| 06/28 - Wednesday | Real Salt Lake | W, 2-1 8:00 p.m. | DK - 10,914 |
| July |
| 07/04 - Tuesday | Kansas City Wizards | W, 1-0 7:00 p.m. | DK, CSN - 10,387 |
| 07/08 - Saturday | New England Revolution | L, 2-1 7:30 p.m. | DK - 11,374 |
| 07/12 - W4dnesday | Club America (Friendly) | L, 2-1 | ESPN2 - 16,172 |
| 07/15 - Saturday | FC Dallas | L, 3-2 3:00 p.m. | ESPN2 - 13,111 |
| 07/22 - Saturday | D.C. United | T, 1-1 7:30 p.m. | DK, CSN - 15,094 |
| 07/29 - Saturday | Columbus Crew | T, 0-0 7:30 p.m. | 11,262 |
| August |
| Saturday, August 5 |
| 2006 Sierra Mist MLS All-Star Game at Bridgeview Stadium |
| MLS All-Stars |
Chelsea FC |
MLS 1, CHL 0 5:30 p.m. |
ESPN - 21,210 |
| 08/12 - Saturday | Chivas USA | L, 2-1 7:30 p.m. | DK - 17,066 |
| 08/14 - Monday | Kansas City Wizards (US Open Cup) | W, 2-0 7:30 p.m. | 5,874 |
| 08/16 - Wednesday | Kansas City Wizards | W, 3-0 8:00 p.m. | 14,239 |
| 08/20 - Sunday | @ New England Revolution | W, 1-0 2:00 p.m. | 10,263 - DK |
| 08/23 - Wednesday | New England Revolution (US Open Cup) | W, 2-1 | 5,214 |
| 08/26 - Saturday | Colorado Rapids | W, 1-0 7:30 p.m. | 15,400 - CSN |
| 08/30 - Wednesday | Houston Dynamo | T, 2-2 8:00 p.m. | 7,858 - DK, CSN |
| September |
| 09/03 - Sunday | New York Red Bulls | W, 2-1 6:00 p.m. | 10,494 - DK, CSN |
| 09/06 - Wednesday | D.C. United (US Open Cup Semifinal) | W, 3-0 7:30 p.m. | 5,153 |
| 09/09 - Saturday | @ Columbus Crew | 6:30 p.m. |
|
| 09/13 - Wednesday | @ Colorado Rapids | 8:30 p.m. | DK |
| 09/17 - Sunday | D.C. United | 3:00 p.m. | ESPN2 |
| 09/23 - Saturday | Los Angeles Galaxy | 7:30 p.m. | HDNet |
| 09/27 - Wednesday | Los Angeles Galaxy (US Open Cup Final) | 7:00 p.m. | - |
| 09/30 - Saturday | @ New York Red Bulls | 6:30 p.m. | DK, CSN |
| October |
| 10/07 - Saturday | Columbus Crew | 7:30 p.m. | DK, CSN |
| 10/15 - Sunday | @ D.C. United | 4:00 p.m. | ESPN2 |
| Sunday, November 12 |
| MLS Cup 2006 at Pizza Hut Park - Frisco, Texas |
2:30 p.m. |
ABC |